PrEP takes about 7 days before it is fully effective in rectal tissue, which is the most common need. For the first week you are on PrEP, you should continue to use condoms every time you have sex in order to prevent HIV. If you are concerned about other STDs (e.g. gonorrhea, chlamydia, herpes, etc.), condom use is encouraged as PrEP is only effective for preventing HIV. It may take longer for PrEP to be effective in vaginal tissue, oral tissue, or for injection drug users, so it is best to talk with your doctor about your specific needs.
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